Spain and the Empire 1519-1643

Npgrj_NN_2011 1519..1528

Expansion of the polyglutamine (polyQ) tract in human TATA-box binding protein (TBP) causes the neurodegenerative disease spinocerebellar ataxia 17 (SCA17). It remains unclear how the polyQ tract regulates normal protein function and induces selective neuropathology in SCA17. We generated transgenic mice expressing polyQ-expanded TBP. These mice showed weight loss, progressive neurological symp...

Dmm021394 1643..1650

Visualization of infection and the associated host response has been challenging in adult vertebrates. Owing to their transparency, zebrafish larvae have been used to directly observe infection in vivo; however, such larvae have not yet developed a functional adaptive immune system. Cells involved in adaptive immunity mature later and have therefore been difficult to access optically in intact ...

The Spacious Word: Cartography, Literature, and Empire in Early Modern Spain

Op-gbev150111 1519..1532

The amino acid composition (AAC) of proteomes differs greatly between microorganisms and is associated with the environmental niche they inhabit, suggesting that these changes may be adaptive. Similarly, the oligonucleotide composition of genomes varies and mayconferadvantagesat theDNA/RNA level. These influencesoverlap inprotein-coding sequences,making itdifficult togauge their relative contri...

Globish and the empire.